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-synuclein, which can be a principal component of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, that is an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) pressure, advise that dysfunction of the intracellular proteinase programs, which include ubiquitin-proteasome system or lysosomal procedure, which removes pointless

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